Mike Hall (sportscaster) and Lipoprotein-associated phospholipase A2

Michael James Hall (born February 1982 in Glen Ellyn, Illinois) is an American sports broadcaster who currently works for the Big Ten Network. He can also be found as a sideline reporter for NFL games on Fox. Hall is a graduate of the University of Missouri where he majored in Journalism.

Contents 1 Biography 1.1 Dream Job 1.2 ESPN 1.3 Big Ten Network and Fox Sports 1.4 Improv comedy 2 References 3 External links

Biography Dream Job

Hall is perhaps best known for being the winner of the first season of ESPN's reality television show Dream Job. For his efforts, Hall won a one-year contract to be an anchor on ESPN's popular sports news program SportsCenter, and a new Mazda3. On the night that he won, March 28, 2004, Hall also took a sports quiz to raise his salary. His salary started at $70,000. He then answered five trivia questions, each correct answer worth $5,000, to bump his first-year salary to $95,000.

On May 15, 2004, Hall graduated from the University of Missouri. At 1 a.m. Eastern Daylight Time on July 20, 2004, Hall began his stint as an official SportsCenter anchor alongside Linda Cohn, having already done some work for ESPNews. Before Missouri, he attended Glenbard West High School.

Mike Hall also appeared on ESPN, and occasionally ESPN2, broadcasting college games including the Division I NCAA Frozen Four National Championship. ESPN

He previously was the featured on-air personality at ESPN's network devoted to college sports, ESPNU. ESPN's Pardon the Interruption reported during its "Happy Trails!" segment on April 27, 2007, that Hall was leaving ESPNU to move back to the Chicago area, where he would pursue other job opportunities. Bleacher Report ranked hall 17th in their list of the 50 worst announcers of all time. Big Ten Network and Fox Sports

As of 2007, Hall is employed with the Big Ten Network. While at the network Hall has hosted Friday Night Tailgate, Big Ten Football Report, BTN Live on Sirius/XM satellite radio, Big Ten Basketball & Beyond and Big Ten Basketball pre-game, halftime, and wrap-up segments.

Hall also makes appearances doing sideline reporting for The NFL on Fox. Improv comedy

Hall performs improv comedy at iO Chicago with Coup de Grace and at The Playground with Boyish.

Lipoprotein-associated phospholipase A2 and Mike Hall (sportscaster)

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7941 27226 Ensembl ENSG00000146070 ENSMUSG00000023913 UniProt Q13093 Q60963 RefSeq (mRNA) NM_001168357 NM_013737 RefSeq (protein) NP_001161829 NP_038765 Location (UCSC) Chr 6: 46.67 – 46.7 Mb Chr 17: 43.57 – 43.61 Mb PubMed search This box: view talk edit

Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45-kDa protein of 441 amino acids. It is one of several PAF acetylhydrolases.

Contents 1 Function 2 Clinical significance 3 See also 4 References 5 Further reading

Function

In the blood it travels mainly with low-density lipoprotein (LDL). Less than 20% is associated with high-density lipoprotein HDL. It is an enzyme produced by inflammatory cells and hydrolyzes oxidized phospholipids in LDL.

Lp-PLA2 is platelet-activating factor (PAF) acetylhydrolase (EC 3.1.1.47), a secreted enzyme that catalyzes the degradation of PAF to inactive products by hydrolysis of the acetyl group at the sn-2 position, producing the biologically inactive products LYSO-PAF and acetate. Clinical significance

Lp-PLA2 is involved in the development of atherosclerosis, an observation that has prompted interest as a possible therapeutic target (see, e.g. the investigational drug Darapladib). In human atherosclerotic lesions, 2 main sources of Lp-PLA2 can be identified, including that which is brought into the intima bound to LDL (from the circulation), and that which is synthesized de novo by plaque inflammatory cells (macrophages, T cells, mast cells)."

It is used as a marker for cardiac disease.

A meta-analysis involving a total of 79,036 participants in 32 prospective studies found that Lp-PLA2 levels are positively correlated with increased risk of developing coronary heart disease and stroke. See also darapladib
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